Preimplantation genetic testing (PGT) is a screening performed on each embryo to identify aneuploid embryos. Aneuploid embryos are embryos that do not have the correct number of chromosomes, whether it be too few or too many. An aneuploidy is the most common cause for a transferred embryo to be unsuccessful.

What does PGT test for?

PGT examines all chromosomes, including the sex chromosomes. Things we can recognize:

  • Chromosomal duplications – An extra copy of chromosomes can result in conditions like down syndrome
  • Chromosomal deletions – Missing copies of chromosomes
  • Sex-chromosome abnormalities – Duplications or deletions of X and Y chromosomes can result in conditions like Klinefelter Syndrome and Turner Syndrome
  • Gender Identification – The gender of an embryo can be identified through PGT testing

When is PGT recommended?

PGT may be recommended to you if:

  • You are over 35
  • You have a family history of chromosome problems
  • You have a history of recurrent miscarriages
  • You have had several unsuccessful cycles of IVF

The PGT process

Step 1. Normal IVF treatment is used to collect and fertilize your eggs

Step 2. The embryo is grown in the laboratory until the cells have divided and the embryo consists of enough cells to collect

Step 3. The cells are removed from the embryo for examination

Step 4. The chromosomes are examined to see how many there are and whether they are normal

Benefits of PGT

PGT testing can have numerous benefits for people looking to conceive, including:

  • The number of embryos with an incorrect number of chromosomes can be minimized before implantation
  • Fewer abnormal embryos transferred resulting in fewer miscarriages
  • Improved implantation rates
  • Reduced spontaneous abortion

For more information on PGT, call the reproductive endocrinologists at Center for Reproductive Medicine today at (612) 863-6137 to schedule your first appointment.